Aldehyde dehydrogenase 2 has cardioprotective effects on myocardial ischaemia/reperfusion injury via suppressing mitophagy

• Main Authors: Wenqing eJi (Author), Yuguo eChen (Author), Shujian eWei (Author), Panpan eHao (Author), Junhui eXing (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mitophagy, a selective form of autophagy, is excessively activated in myocardial ischemia/reperfusion (I/R). The study investigated whether aldehyde dehydrogenase (ALDH2) exerted its cardioprotective effect by regulating mitophagy. Myocardial infarct size and apoptosis after I/R in rats were amelior...