Aldehyde dehydrogenase 2 has cardioprotective effects on myocardial ischaemia/reperfusion injury via suppressing mitophagy

• Main Authors: Wenqing eJi (Author), Yuguo eChen (Author), Shujian eWei (Author), Panpan eHao (Author), Junhui eXing (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Mitophagy, a selective form of autophagy, is excessively activated in myocardial ischemia/reperfusion (I/R). The study investigated whether aldehyde dehydrogenase (ALDH2) exerted its cardioprotective effect by regulating mitophagy. Myocardial infarct size and apoptosis after I/R in rats were ameliorated by Alda-1, an ALDH2 activator, and aggravated by ALDH2 inhibition. Both in I/R rats and hypoxia/reoxygenation H9C2 cells, ALDH2 activation suppressed phosphatase and tensin homolog-induced putative kinase 1 (PINK1)/Parkin expression, regulating mitophagy, by preventing 4-hydroxynonenal and reactive oxygen species accumulation. Furthermore, the effect was enhanced by ALDH2 inhibition. Thus, ALDH2 may protect hearts against I/R injury by suppressing PINK1/Parkin-dependent mitophagy.

Item Description

1663-9812
10.3389/fphar.2016.00101