Transcriptome and Lipid Metabolomics-Based Discovery: Glycyrrhizic Acid Alleviates Tripterygium Glycoside Tablet-Induced Acute Liver Injury by Regulating the Activities of CYP and the Metabolism of Phosphoglycerides

• Main Authors: Qiaoli Shi (Author), Qixin Wang (Author), Jiayun Chen (Author), Fei Xia (Author), Chong Qiu (Author), Min Li (Author), Minghong Zhao (Author), Qian Zhang (Author), Piao Luo (Author), Tianming Lu (Author), Ying Zhang (Author), Liting Xu (Author), Xueling He (Author), Tianyu Zhong (Author), Na Lin (Author), Qiuyan Guo (Author)
• Format: Bog
• Udgivet: Frontiers Media S.A., 2022-02-01T00:00:00Z.
• Fag: article
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Background: Glycyrrhizic acid (GA) has been reported to be liver protective; however, the characters and underlying mechanisms of GA against tripterygium glycoside tablet (TGT)-induced acute liver injury remain unelucidated.Hypothesis/Purpose: We assumed that GA could relieve TGT-induced acute liver...