A multi-scale modeling framework for individualized, spatiotemporal prediction of drug effects and toxicological risk

• Main Authors: Juan Guillermo eDiaz Ochoa (Author), Joachim eBucher (Author), Alexandre R.R. Pery (Author), José M. Zaldivar Comenges (Author), Jens eNiklas (Author), Klaus eMauch (Author)
• Format: Book
• Published: Frontiers Media S.A., 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, we focus on a novel multi-scale modeling approach for spatiotemporal prediction of the distribution of substances and resulting hepatotoxicity by combining cellular models, a 2D liver model, and whole-body model. As a case study, we focused on predicting human hepatotoxicity upon trea...