Quantitative prediction of pharmacokinetic properties of drugs in humans: Recent advance in in vitro models to predict the impact of efflux transporters in the small intestine and blood-brain barrier

• Main Authors: Yoshiki Hashimoto (Author), Kazuyoshi Michiba (Author), Kazuya Maeda (Author), Hiroyuki Kusuhara (Author)
• 格式: 圖書
• 出版: Elsevier, 2022-01-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

Efflux transport systems are essential to suppress the absorption of xenobiotics from the intestinal lumen and protect the critical tissues at the blood-tissue barriers, such as the blood-brain barrier. The function of drug efflux transport is dominated by various transporters. Accumulated clinical...