A Rare Case of Autoimmune Demyelinating Polyneuropathy and Hydrocephalus Secondary to Pembrolizumab

• Main Authors: Aakriti Arora BS (Author), Amar Shere MD (Author), Kunal Patel MD (Author), Nuwan Gunawardhana MD (Author), Ericka LiFuentes MD (Author)
• Format: Book
• Published: SAGE Publishing, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pembrolizumab is a humanized monoclonal antibody that targets the programmed cell death 1 protein (PD-1) receptor and blocks the inhibitory checkpoint interaction between PD-1 and its ligands. This interaction leads to the upregulation of effector T-cells and downregulating regulatory T-cell product...