Clinical pharmacology of vc-MMAE antibody-drug conjugates in cancer patients: learning from eight first-in-human Phase 1 studies

• Main Authors: Chunze Li (Author), Cindy Zhang (Author), Zao Li (Author), Divya Samineni (Author), Dan Lu (Author), Bei Wang (Author), Shang-Chiung Chen (Author), Rong Zhang (Author), Priya Agarwal (Author), Bernard M. Fine (Author), Sandhya Girish (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

vc-MMAE antibody-drug conjugates (ADCs) consist of a monoclonal antibody (mAb) covalently bound with a potent anti-mitotic toxin (MMAE) through a protease-labile valine-citrulline (vc) linker. The objective of this study was to characterize the pharmacokinetics (PK) and explore exposure-response rel...