Clinical pharmacology of vc-MMAE antibody-drug conjugates in cancer patients: learning from eight first-in-human Phase 1 studies

• Prif Awduron: Chunze Li (Awdur), Cindy Zhang (Awdur), Zao Li (Awdur), Divya Samineni (Awdur), Dan Lu (Awdur), Bei Wang (Awdur), Shang-Chiung Chen (Awdur), Rong Zhang (Awdur), Priya Agarwal (Awdur), Bernard M. Fine (Awdur), Sandhya Girish (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

vc-MMAE antibody-drug conjugates (ADCs) consist of a monoclonal antibody (mAb) covalently bound with a potent anti-mitotic toxin (MMAE) through a protease-labile valine-citrulline (vc) linker. The objective of this study was to characterize the pharmacokinetics (PK) and explore exposure-response rel...