Small molecule drug discovery targeting the JAK-STAT pathway

• Main Authors: You Lv (Author), Pengbing Mi (Author), Jeffrey J. Babon (Author), Guohuang Fan (Author), Jianxun Qi (Author), Longxing Cao (Author), Jiajia Lang (Author), Jin Zhang (Author), Faming Wang (Author), Bostjan Kobe (Author)
• Formato: Livro
• Publicado em: Elsevier, 2024-06-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway functions as a central hub for transmitting signals from more than 50 cytokines, playing a pivotal role in maintaining hematopoiesis, immune balance, and tissue homeostasis. Dysregulation of this pathway has been im...