Application of Physiologically Based Pharmacokinetic Modeling in Preclinical Studies: A Feasible Strategy to Practice the Principles of 3Rs

• Main Authors: Yawen Yuan (Author), Qingfeng He (Author), Shunguo Zhang (Author), Min Li (Author), Zhijia Tang (Author), Xiao Zhu (Author), Zheng Jiao (Author), Weimin Cai (Author), Xiaoqiang Xiang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pharmacokinetic characterization plays a vital role in drug discovery and development. Although involving numerous laboratory animals with error-prone, labor-intensive, and time-consuming procedures, pharmacokinetic profiling is still irreplaceable in preclinical studies. With physiologically based...