Selective and Irreversible Induction of Necroptotic Cell Death in Lung Tumorspheres by Short-Term Exposure to Verapamil in Combination with Sorafenib

• Autori principali: Juan Sebastian Yakisich (Autore), Yogesh Kulkarni (Autore), Neelam Azad (Autore), Anand Krishnan V. Iyer (Autore)
• Natura: Libro
• Pubblicazione: Hindawi Limited, 2017-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

The presence of highly resistant cancer cells and the toxicity to normal cells are key factors that limit chemotherapy. Here, we used two models of highly resistant lung cancer cells: (1) adherent cells growing under prolonged periods of serum starvation (PPSS) and (2) cells growing as floating tumo...