Increased Levels of Fatty Acids Contributed to Induction of Hepatic CYP3A4 Activity Induced by Diabetes - In Vitro Evidence From HepG2 Cell and Fa2N-4 Cell Lines

• Main Authors: Nan Hu (Author), Mengyue Hu (Author), Ru Duan (Author), Can Liu (Author), Haifang Guo (Author), Mian Zhang (Author), Yunli Yu (Author), Xinting Wang (Author), Li Liu (Author), Xiaodong Liu (Author)
• Format: Book
• Published: Elsevier, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Accumulating evidences have shown that diabetes upregulated the function and expression of CYP3A4, but the mechanism remained unclear. In this study, HepG2 cells were incubated with serum from diabetic rats induced by streptozotocin, and the activity of CYP3A4 was measured by substrate metabolism. R...