Icariin Alleviates Wear Particle-Induced Periprosthetic Osteolysis via Down-Regulation of the Estrogen Receptor α-mediated NF-κB Signaling Pathway in Macrophages

• Main Authors: Fu Guangtao (Author), Wen Zhenkang (Author), Deng Zhantao (Author), Li Mengyuan (Author), Li Qingtian (Author), Ma Yuanchen (Author), Chen Yuanfeng (Author), Zheng Qiujian (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Periprosthetic osteolysis is one of the major long-term complications following total joint replacement. Its cause is widely accepted to be wear particle-induced activation of inflammatory macrophages. No effective strategy for the prevention and treatment of periprosthetic osteolysis is yet availab...