Enhanced skin localization of doxycycline using microparticles and hydrogel: effect of oleic acid as penetration enhancer

• Main Authors: Aliyah Aliyah (Author), Windy Winalda Oktaviana (Author), Kadek Saka Dwipayanti (Author), Arini Putri Erdiana (Author), Rifka Nurul Utami (Author), Andi Dian Permana (Author)
• Format: Book
• Published: Universitas Ahmad Dahlan, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

One of the disadvantages of gel preparations is the poor ability to penetrate the skin. Herein we developed a sodium carboxymethylcellulose (NaCMC)-based gel containing microparticle of doxycycline hyclate (DOX). Oleic acid (OA) was added into the gel formulation specifically to increase the penetra...