Enhanced skin localization of doxycycline using microparticles and hydrogel: effect of oleic acid as penetration enhancer

• Үндсэн зохиолчид: Aliyah Aliyah (Зохиогч), Windy Winalda Oktaviana (Зохиогч), Kadek Saka Dwipayanti (Зохиогч), Arini Putri Erdiana (Зохиогч), Rifka Nurul Utami (Зохиогч), Andi Dian Permana (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Universitas Ahmad Dahlan, 2021-07-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

One of the disadvantages of gel preparations is the poor ability to penetrate the skin. Herein we developed a sodium carboxymethylcellulose (NaCMC)-based gel containing microparticle of doxycycline hyclate (DOX). Oleic acid (OA) was added into the gel formulation specifically to increase the penetra...