Antipsychotic Potential of Quinazoline ErbB1 Inhibitors in a Schizophrenia Model Established With Neonatal Hippocampal Lesioning

• Main Authors: Makoto Mizuno (Author), Yuriko Iwakura (Author), Masako Shibuya (Author), Yingjun Zheng (Author), Takeyoshi Eda (Author), Taisuke Kato (Author), Yohei Takasu (Author), Hiroyuki Nawa (Author)
• Format: Book
• Published: Elsevier, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract.: Hyper-signaling of the epidermal growth factor receptor family (ErbB) is implicated in the pathophysiology of schizophrenia. Various quinazoline inhibitors targeting ErbB1 or ErbB2 - 4 have been developed as anti-cancer agents and might be useful for antipsychotic treatment. In the presen...