Antipsychotic Potential of Quinazoline ErbB1 Inhibitors in a Schizophrenia Model Established With Neonatal Hippocampal Lesioning

• मुख्य लेखकों: Makoto Mizuno (लेखक), Yuriko Iwakura (लेखक), Masako Shibuya (लेखक), Yingjun Zheng (लेखक), Takeyoshi Eda (लेखक), Taisuke Kato (लेखक), Yohei Takasu (लेखक), Hiroyuki Nawa (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2010-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract.: Hyper-signaling of the epidermal growth factor receptor family (ErbB) is implicated in the pathophysiology of schizophrenia. Various quinazoline inhibitors targeting ErbB1 or ErbB2 - 4 have been developed as anti-cancer agents and might be useful for antipsychotic treatment. In the presen...