Degradation kinetics of larotaxel and identification of its degradation products in alkaline condition

• Autori principali: Xiaoming Liang (Autore), Zhenzhen Liu (Autore), Huiyan Shi (Autore), Yuanyuan Zhang (Autore), Shixiao Wang (Autore), Kaishun Bi (Autore), Xiaohui Chen (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2017-04-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Larotaxel, a new taxane compound prepared by partial synthesis from 10-deacetyl baccatin III, is active against tumors. In this research, a selective LC-MS method was developed and validated for the study of degradation kinetics of larotaxel, which was carried out in aqueous solutions with different...