Degradation kinetics of larotaxel and identification of its degradation products in alkaline condition

• Main Authors: Xiaoming Liang (Author), Zhenzhen Liu (Author), Huiyan Shi (Author), Yuanyuan Zhang (Author), Shixiao Wang (Author), Kaishun Bi (Author), Xiaohui Chen (Author)
• Format: Book
• Published: Elsevier, 2017-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Larotaxel, a new taxane compound prepared by partial synthesis from 10-deacetyl baccatin III, is active against tumors. In this research, a selective LC-MS method was developed and validated for the study of degradation kinetics of larotaxel, which was carried out in aqueous solutions with different...