Synthesis and Human Carbonic Anhydrase I, II, IX, and XII Inhibition Studies of Sulphonamides Incorporating Mono-, Bi- and Tricyclic Imide Moieties

• 主要な著者: Kalyan K. Sethi (著者), KM Abha Mishra (著者), Saurabh M. Verma (著者), Daniela Vullo (著者), Fabrizio Carta (著者), Claudiu T. Supuran (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2021-07-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

New derivatives were synthesised by reaction of amino-containing aromatic sulphonamides with mono-, bi-, and tricyclic anhydrides. These sulphonamides were investigated as human carbonic anhydrases (hCAs, EC 4.2.1.1) I, II, IX, and XII inhibitors. hCA I was inhibited with inhibition constants (Kis)...