Nrg4 promotes fuel oxidation and a healthy adipokine profile to ameliorate diet-induced metabolic disorders

• Main Authors: Zhimin Chen (Author), Guo-Xiao Wang (Author), Sara L. Ma (Author), Dae Young Jung (Author), Hyekyung Ha (Author), Tariq Altamimi (Author), Xu-Yun Zhao (Author), Liang Guo (Author), Peng Zhang (Author), Chun-Rui Hu (Author), Ji-Xin Cheng (Author), Gary D. Lopaschuk (Author), Jason K. Kim (Author), Jiandie D. Lin (Author)
• Format: Book
• Published: Elsevier, 2017-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Brown and white adipose tissue exerts pleiotropic effects on systemic energy metabolism in part by releasing endocrine factors. Neuregulin 4 (Nrg4) was recently identified as a brown fat-enriched secreted factor that ameliorates diet-induced metabolic disorders, including insulin resistan...