Hazards of Using Masking Protocols When Performing Ligand Binding Assays: Lessons From the Sigma-1 and Sigma-2 Receptors

• Päätekijät: Haider Abbas (Tekijä), Preeti Borde (Tekijä), Gary B. Willars (Tekijä), David R. Ferry (Tekijä), Stephen T. Safrany (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Frontiers Media S.A., 2020-03-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Sigma-1 and sigma-2 receptors are emerging therapeutic targets. Although the molecular identity of the sigma-2 receptor has recently been determined, receptor quantitation has used, and continues to use, the sigma-1 selective agents (+) pentazocine or dextrallorphan to mask the sigma-1 receptor in r...