Angiosarcoma in HIV-negative patients is not associated with HHV-8

• Main Authors: João Avancini (Author), José Antonio Sanches (Author), Andre Pires Zanata Cherubim (Author), Renato Pazzini (Author), Cristina Mendes de Oliveira (Author), Laura Masami Sumita (Author), Neusa Yuriko Sakai Valente (Author), Claudio Sergio Pannuti (Author), Cyro Festa Neto (Author)
• Format: Book
• Published: Sociedade Brasileira de Dermatologia, 2016-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Abstract: BACKGROUND: Angiosarcoma is an aggressive, malignant neoplasm of vascular or lymphatic origin. Herpes virus 8 (HHV-8) is a member of the herpes family with a tropism for endothelial cells and it has been proven to induce vascular neoplasms, such as Kaposi's sarcoma. The role of HHV-8 in the pathogenesis of angiosarcoma has not been well defined. OBJECTIVE: To investigate the relationship between the presence of HHV-8 and angiosarcoma. METHODS: In this study, the team investigated the relationship between the presence of HHV-8, as determined by polymerase chain reaction, and angiosarcoma, using samples from patients with epidemic Kaposi's sarcoma as controls. RESULTS: While all control cases with epidemic Kaposi's sarcoma were positive for HHV-8, none of the angiosarcoma cases was. CONCLUSION: These findings support most previous studies that found no association between HHV-8 and angiosarcoma.

Item Description

0365-0596
10.1590/abd1806-4841.20164730