Anticancer Activity of the Choline Kinase Inhibitor PL48 Is Due to Selective Disruption of Choline Metabolism and Transport Systems in Cancer Cell Lines

• Main Authors: Pablo García-Molina (Author), Alberto Sola-Leyva (Author), Pilar M. Luque-Navarro (Author), Alejandro Laso (Author), Pablo Ríos-Marco (Author), Antonio Ríos (Author), Daniela Lanari (Author), Archimede Torretta (Author), Emilio Parisini (Author), Luisa C. López-Cara (Author), Carmen Marco (Author), María P. Carrasco-Jiménez (Author)
• Format: Book
• Published: MDPI AG, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A large number of different types of cancer have been shown to be associated with an abnormal metabolism of phosphatidylcholine (PC), the main component of eukaryotic cell membranes. Indeed, the overexpression of choline kinase α1 (ChoKα1), the enzyme that catalyses the bioconversion of choline to p...