TC-2559, an α4β2 nicotinic acetylcholine receptor agonist, suppresses the expression of CCL3 and IL-1β through STAT3 inhibition in cultured murine macrophages

• Main Authors: Norikazu Kiguchi (Author), Fumihiro Saika (Author), Yuka Kobayashi (Author), Mei-Chuan Ko (Author), Shiroh Kishioka (Author)
• Format: Book
• Published: Elsevier, 2015-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The anti-inflammatory properties of TC-2559, an α4β2 nicotinic acetylcholine receptor (nAChR) agonist, on cultured murine macrophages was investigated. TC-2559 suppressed the upregulation of CC-chemokine ligand 3 (CCL3) and interleukin-1β (IL-1β) following lipopolysaccharide (LPS) treatment in J774A...