Successful Treatment of Human Visceral Leishmaniasis Restores Antigen-Specific IFN-γ, but not IL-10 Production.

• Main Authors: Emebet Adem (Author), Fitsumbirhan Tajebe (Author), Mulusew Getahun (Author), Amare Kiflie (Author), Ermias Diro (Author), Asrat Hailu (Author), Ziv Shkedy (Author), Bewketu Mengesha (Author), Tadele Mulaw (Author), Saba Atnafu (Author), Tekalign Deressa (Author), Biniam Mathewos (Author), Ebba Abate (Author), Manuel Modolell (Author), Markus Munder (Author), Ingrid Müller (Author), Yegnasew Takele (Author), Pascale Kropf (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

One of the key immunological characteristics of active visceral leishmaniasis (VL) is a profound immunosuppression and impaired production of Interferon-γ (IFN-γ). However, recent studies from Bihar in India showed using a whole blood assay, that whole blood cells have maintained the capacity to pro...