RPN2 Gene Confers Osteosarcoma Cell Malignant Phenotypes and Determines Clinical Prognosis

• Main Authors: Tomohiro Fujiwara (Author), Ryou-u Takahashi (Author), Nobuyoshi Kosaka (Author), Yutaka Nezu (Author), Akira Kawai (Author), Toshifumi Ozaki (Author), Takahiro Ochiya (Author)
• Format: Book
• Published: Elsevier, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Drug resistance and metastasis are lethal characteristics of tumors. We previously demonstrated that silencing of ribophorin II (RPN2), which is part of the N-oligosaccharyl transferase complex, efficiently induced apoptosis and reduced resistance to docetaxel in human breast cancer cells. Here, we...