A Novel BRD Family PROTAC Inhibitor dBET1 Exerts Great Anti-Cancer Effects by Targeting c-MYC in Acute Myeloid Leukemia Cells

• Main Authors: Kunlong Zhang (Author), Li Gao (Author), Jianwei Wang (Author), Xinran Chu (Author), Zimu Zhang (Author), Yongping Zhang (Author), Fang Fang (Author), Yanfang Tao (Author), Xiaolu Li (Author), Yuanyuan Tian (Author), Zhiheng Li (Author), Xu Sang (Author), Li Ma (Author), Lihui Lu (Author), Yanling Chen (Author), Juanjuan Yu (Author), Ran Zhuo (Author), Shuiyan Wu (Author), Jian Pan (Author), Shaoyan Hu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acute myeloid leukemia (AML) represents an aggressive hematopoietic malignancy with a prognosis inferior to that of other leukemias. Recent targeted therapies offer new opportunities to achieve better treatment outcomes. However, due to the complex heterogeneity of AML, its prognosis remains dismal....