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Isoxazol-5(2H)-one: a new scaffold for potent human neutrophil elastase (HNE) inhibitors

Human neutrophil elastase (HNE) is an important target for the development of novel and selective inhibitors to treat inflammatory diseases, especially pulmonary pathologies. Here, we report the synthesis, structure-activity relationship analysis, and biological evaluation of a new series of HNE inh...

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Bibliographic Details
Main Authors: Claudia Vergelli (Author), Igor A. Schepetkin (Author), Letizia Crocetti (Author), Antonella Iacovone (Author), Maria Paola Giovannoni (Author), Gabriella Guerrini (Author), Andrei I. Khlebnikov (Author), Samuele Ciattini (Author), Giovanna Ciciani (Author), Mark T. Quinn (Author)
Format: Book
Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
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