Polyethylenimine Nanoparticle-Mediated siRNA Delivery to Reduce α-Synuclein Expression in a Model of Parkinson's Disease

• Main Authors: Christin Helmschrodt (Author), Sabrina Höbel (Author), Sandra Schöniger (Author), Anne Bauer (Author), Jana Bonicelli (Author), Marieke Gringmuth (Author), Simone A. Fietz (Author), Achim Aigner (Author), Angelika Richter (Author), Franziska Richter (Author)
• Format: Book
• Published: Elsevier, 2017-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

RNA interference (RNAi)-based strategies that mediate the specific knockdown of target genes by administration of small interfering RNAs (siRNAs) could be applied for treatment of presently incurable neurodegenerative diseases such as Parkinson's disease. However, inefficient delivery of siRNA...