Cost Implications of Reactive Versus Prospective Testing for Dihydropyrimidine Dehydrogenase Deficiency in Patients With Colorectal Cancer: A Single-Institution Experience

• Main Authors: Con Murphy (Author), Stephen Byrne (Author), Gul Ahmed (Author), Andrew Kenny (Author), James Gallagher (Author), Harry Harvey (Author), Eoin O'Farrell (Author), Brian Bird (Author)
• Format: Book
• Published: SAGE Publishing, 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Severe toxicity is experienced by a substantial minority of patients receiving fluoropyrimidine-based chemotherapy, with approximately 20% of these severe toxicities attributable to polymorphisms in the DPYD gene. The DPYD codes for the enzyme dihydropyrimidine dehydrogenase (DPD) import...