Cost Implications of Reactive Versus Prospective Testing for Dihydropyrimidine Dehydrogenase Deficiency in Patients With Colorectal Cancer: A Single-Institution Experience

• Asıl Yazarlar: Con Murphy (Yazar), Stephen Byrne (Yazar), Gul Ahmed (Yazar), Andrew Kenny (Yazar), James Gallagher (Yazar), Harry Harvey (Yazar), Eoin O'Farrell (Yazar), Brian Bird (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: SAGE Publishing, 2018-09-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Background: Severe toxicity is experienced by a substantial minority of patients receiving fluoropyrimidine-based chemotherapy, with approximately 20% of these severe toxicities attributable to polymorphisms in the DPYD gene. The DPYD codes for the enzyme dihydropyrimidine dehydrogenase (DPD) import...