Cost Implications of Reactive Versus Prospective Testing for Dihydropyrimidine Dehydrogenase Deficiency in Patients With Colorectal Cancer: A Single-Institution Experience

• Autores principales: Con Murphy (Autor), Stephen Byrne (Autor), Gul Ahmed (Autor), Andrew Kenny (Autor), James Gallagher (Autor), Harry Harvey (Autor), Eoin O'Farrell (Autor), Brian Bird (Autor)
• Formato: Libro
• Publicado: SAGE Publishing, 2018-09-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Background: Severe toxicity is experienced by a substantial minority of patients receiving fluoropyrimidine-based chemotherapy, with approximately 20% of these severe toxicities attributable to polymorphisms in the DPYD gene. The DPYD codes for the enzyme dihydropyrimidine dehydrogenase (DPD) import...