Haplotype analysis of BRCA1 intragenic markers in Iranian patients with familial breast and ovarian cancer

• Main Authors: Seyed Mohsen Miresmaeili (Author), Dor Mohammad Kordi Tamandani (Author), Seyed Mehdi Kalantar (Author), Seyed Mohammad Moshtaghioun (Author)
• Format: Book
• Published: Shahid Sadoughi University of Medical Science, Yazd, Iran, 2016-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Breast cancer is the most common malignancy in women. Breast Cancer Type 1 Susceptibility gene (BRCA1) is a tumor suppressor gene, involved in DNA damage repair and in 81% of the breast-ovarian cancer families were due to BRCA1. In some clinically investigated genes, the intragenic marke...