Glycoprotein A33 deficiency: a new mouse model of impaired intestinal epithelial barrier function and inflammatory disease

• Main Authors: Benjamin B. Williams (Author), Niall C. Tebbutt (Author), Michael Buchert (Author), Tracy L. Putoczki (Author), Karen Doggett (Author), Shisan Bao (Author), Cameron N. Johnstone (Author), Frederick Masson (Author), Frederic Hollande (Author), Antony W. Burgess (Author), Andrew M. Scott (Author), Matthias Ernst (Author), Joan K. Heath (Author)
• Format: Book
• Published: The Company of Biologists, 2015-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The cells of the intestinal epithelium provide a selectively permeable barrier between the external environment and internal tissues. The integrity of this barrier is maintained by tight junctions, specialised cell-cell contacts that permit the absorption of water and nutrients while excluding micro...