The <it>G-308A</it> variant of the Tumor Necrosis Factor-α (<it>TNF-α</it>) gene is not associated with obesity, insulin resistance and body fat distribution

• Main Authors: Vecci Elio (Author), Berni Andrea (Author), Arca Marcello (Author), Capici Francesca (Author), Sentinelli Federica (Author), Romeo Stefano (Author), Di Mario Umberto (Author), Baroni Marco (Author)
• Format: Book
• Published: BMC, 2001-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Tumor Necrosis Factor-α (TNF-α) has been implicated in the pathogenesis of insulin resistance and obesity. The increased expression of TNF-α in adipose tissue has been shown to induce insulin resistance, and a polymorphism at positio...