In Silico Profiling of Histone Deacetylase 8 Inhibitory Activity: A Computational Analysis of Novel Dipeptide-Based Compounds Cross-Linked with Hydroxamic Acid

• Hoofdauteurs: omer mohammed ammash (Auteur), Shakir M. Alwan (Auteur), Ali R.M. albakaa (Auteur), İsmail Alshrif Ibrheam ben Sulaiman (Auteur)
• Formaat: Boek
• Gepubliceerd in: College of Pharmacy / Mustansiriyah University, 2024-04-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

This study involved the development of innovative compounds consisting of dipeptide cross-links combined with hydroxamic acid. Our objective was to assess their binding affinities with histone deacetylase 8 (HDAC8) by conducting a docking study, comparing the results with the reference ligand, suber...