Kinetic modeling of the plasma pharmacokinetic profiles of ADAMTS13 fragment and its Fc-fusion counterpart in mice

• Hauptverfasser: Heechun Kwak (Verfasst von), Min-Soo Kim (Verfasst von), Suyong Kim (Verfasst von), Jiyoung Kim (Verfasst von), Yasunori Aoki (Verfasst von), Suk-Jae Chung (Verfasst von), Hyun-Ja Nam (Verfasst von), Wooin Lee (Verfasst von)
• Format: Buch
• Veröffentlicht: Frontiers Media S.A., 2024-03-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Introduction: Fusion of the fragment crystallizable (Fc) to protein therapeutics is commonly used to extend the circulation time by enhancing neonatal Fc-receptor (FcRn)-mediated endosomal recycling and slowing renal clearance. This study applied kinetic modeling to gain insights into the cellular p...