Kinetic modeling of the plasma pharmacokinetic profiles of ADAMTS13 fragment and its Fc-fusion counterpart in mice

Kinetic modeling of the plasma pharmacokinetic profiles of ADAMTS13 fragment and its Fc-fusion counterpart in mice

Introduction: Fusion of the fragment crystallizable (Fc) to protein therapeutics is commonly used to extend the circulation time by enhancing neonatal Fc-receptor (FcRn)-mediated endosomal recycling and slowing renal clearance. This study applied kinetic modeling to gain insights into the cellular p...

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Main Authors: Heechun Kwak (Author), Min-Soo Kim (Author), Suyong Kim (Author), Jiyoung Kim (Author), Yasunori Aoki (Author), Suk-Jae Chung (Author), Hyun-Ja Nam (Author), Wooin Lee (Author)
Format: Book
Published: Frontiers Media S.A., 2024-03-01T00:00:00Z.
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