Hepatic OATP1B zonal distribution: Implications for rifampicin‐mediated drug-drug interactions explored within a PBPK framework

• Main Authors: Mattie Hartauer (Author), William A. Murphy (Author), Kim L. R. Brouwer (Author), Roz Southall (Author), Sibylle Neuhoff (Author)
• Format: Bog
• Udgivet: Wiley, 2024-09-01T00:00:00Z.
• Fag: article
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Abstract OATP1B facilitates the uptake of xenobiotics into hepatocytes and is a prominent target for drug-drug interactions (DDIs). Reduced systemic exposure of OATP1B substrates has been reported following multiple‐dose rifampicin; one explanation for this observation is OATP1B induction. Non‐unifo...