Hepatic OATP1B zonal distribution: Implications for rifampicin‐mediated drug-drug interactions explored within a PBPK framework
Abstract OATP1B facilitates the uptake of xenobiotics into hepatocytes and is a prominent target for drug-drug interactions (DDIs). Reduced systemic exposure of OATP1B substrates has been reported following multiple‐dose rifampicin; one explanation for this observation is OATP1B induction. Non‐unifo...
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| Main Authors: | , , , , |
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| Format: | Book |
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Wiley,
2024-09-01T00:00:00Z.
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Internet
Connect to this object online.3rd Floor Main Library
| Call Number: |
A1234.567 |
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| Copy 1 | Available |