Alzheimer's disease therapeutic candidate SAK3 is an enhancer of T-type calcium channels

• Главные авторы: Kohji Fukunaga (Автор), Hisanao Izumi (Автор), Yasushi Yabuki (Автор), Yasuharu Shinoda (Автор), Norifumi Shioda (Автор), Feng Han (Автор)
• Формат: ‌
• Опубликовано: Elsevier, 2019-02-01T00:00:00Z.
• Предметы: article
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Low-threshold Ca2+ spikes are mediated by T-type Ca2+ channels, which have electrophysiological properties of fast inactivation and slow deactivation kinetics. A low membrane potential of approximately −60 mV is sufficient to trigger channel opening. We recently introduced a novel T-type Ca2+ channe...