Alzheimer's disease therapeutic candidate SAK3 is an enhancer of T-type calcium channels

• Main Authors: Kohji Fukunaga (Author), Hisanao Izumi (Author), Yasushi Yabuki (Author), Yasuharu Shinoda (Author), Norifumi Shioda (Author), Feng Han (Author)
• Format: Book
• Published: Elsevier, 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Low-threshold Ca2+ spikes are mediated by T-type Ca2+ channels, which have electrophysiological properties of fast inactivation and slow deactivation kinetics. A low membrane potential of approximately −60 mV is sufficient to trigger channel opening. We recently introduced a novel T-type Ca2+ channe...