Pharmacokinetics of Piperacillin-Tazobactam in Critically Ill Patients with Open Abdomen and Vacuum-Assisted Wound Closure: Dosing Considerations Using Monte Carlo Simulation

Background: Open abdomen with vacuum-assisted wound closure therapy (OA/VAC) is frequently used in critically ill patients although the impact of OA/VAC on antibiotics pharmacokinetics (PK) remains unknown. We thus aimed to characterize the PK of piperacillin-tazobactam (PTZ) in critically ill patie...

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Main Authors: Cédric Carrié (Author), Jesse Butruille (Author), Sophie Maingault (Author), Alexandre Lannou (Author), Vincent Dubuisson (Author), Laurent Petit (Author), Matthieu Biais (Author), Dominique Breilh (Author)
Format: Book
Published: MDPI AG, 2024-09-01T00:00:00Z.
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