Pharmacokinetics of Piperacillin-Tazobactam in Critically Ill Patients with Open Abdomen and Vacuum-Assisted Wound Closure: Dosing Considerations Using Monte Carlo Simulation

• Asıl Yazarlar: Cédric Carrié (Yazar), Jesse Butruille (Yazar), Sophie Maingault (Yazar), Alexandre Lannou (Yazar), Vincent Dubuisson (Yazar), Laurent Petit (Yazar), Matthieu Biais (Yazar), Dominique Breilh (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: MDPI AG, 2024-09-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Background: Open abdomen with vacuum-assisted wound closure therapy (OA/VAC) is frequently used in critically ill patients although the impact of OA/VAC on antibiotics pharmacokinetics (PK) remains unknown. We thus aimed to characterize the PK of piperacillin-tazobactam (PTZ) in critically ill patie...