Overexpression of Fgfr2c causes craniofacial bone hypoplasia and ameliorates craniosynostosis in the Crouzon mouse

• Päätekijät: Kevin K. L. Lee (Tekijä), Emma Peskett (Tekijä), Charlotte M. Quinn (Tekijä), Rosanna Aiello (Tekijä), Liliya Adeeva (Tekijä), Dale A. Moulding (Tekijä), Philip Stanier (Tekijä), Erwin Pauws (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: The Company of Biologists, 2018-11-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

FGFR2c regulates many aspects of craniofacial and skeletal development. Mutations in the FGFR2 gene are causative of multiple forms of syndromic craniosynostosis, including Crouzon syndrome. Paradoxically, mouse studies have shown that the activation (Fgfr2cC342Y; a mouse model for human Crouzon syn...