Repurposing Clinical Drugs as AdoMetDC Inhibitors Using the SCAR Strategy

• Main Authors: Yan Zhang (Author), Qiang Zheng (Author), Yin Zhou (Author), Sen Liu (Author)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2020-03-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

With the escalating costs in drug development, discovering new uses of approved drugs, i.e., drug repurposing, has attracted increasing interest. Spermidine and spermine are important polyamines for most cells and their biosynthesis are strictly regulated by the polyamine metabolic network. In cance...