multi-patient dose synthesis of [18F]Flumazenil via a copper-mediated 18F-fluorination

• Main Authors: Thibault Gendron (Author), Gianluca Destro (Author), Natan J. W. Straathof (Author), Jeroen B. I. Sap (Author), Florian Guibbal (Author), Charles Vriamont (Author), Claire Caygill (Author), John R. Atack (Author), Andrew J. Watkins (Author), Christopher Marshall (Author), Rebekka Hueting (Author), Corentin Warnier (Author), Véronique Gouverneur (Author), Matthew Tredwell (Author)
• Format: Bog
• Udgivet: SpringerOpen, 2022-03-01T00:00:00Z.
• Fag: article
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Abstract Background Flumazenil (FMZ) is a functionally silent imidazobenzodiazepine which binds to the benzodiazepine binding site of approximately 75% of the brain γ-aminobutyric acid-A receptors (GABAARs). Positron Emission Tomography (PET) imaging of the GABAARs with [11C]FMZ has been used to evi...