Particle Forming Amorphous Solid Dispersions: A Mechanistic Randomized Pharmacokinetic Study in Humans

• Main Authors: Andreas Schittny (Author), Samuel Waldner (Author), Urs Duthaler (Author), Alexander Vorobyev (Author), Rimma Abramovich (Author), Stephan Krähenbühl (Author), Maxim Puchkov (Author), Jörg Huwyler (Author)
• Format: Book
• Published: MDPI AG, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Amorphous solid dispersions (ASDs) are a promising drug-delivery strategy to overcome poor solubility through formulation. Currently, the understanding of drug absorption mechanisms from ASDs in humans is incomplete. Aiming to gain insights in this matter, we conducted a randomized cross-over design...