Nrf2 as a Therapeutic Target in the Resistance to Targeted Therapies in Melanoma

• Main Authors: Marie Angèle Cucci (Author), Margherita Grattarola (Author), Chiara Monge (Author), Antonella Roetto (Author), Giuseppina Barrera (Author), Emilia Caputo (Author), Chiara Dianzani (Author), Stefania Pizzimenti (Author)
• Format: Book
• Published: MDPI AG, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The use of specific inhibitors towards mutant BRAF (BRAFi) and MEK (MEKi) in BRAF-mutated patients has significantly improved progression-free and overall survival of metastatic melanoma patients. Nevertheless, half of the patients still develop resistance within the first year of therapy. Therefore...