Antigenic landscapes on Staphylococcus aureus pore-forming toxins reveal insights into specificity and cross-neutralization

• Main Authors: Shweta Kailasan (Author), Ravi Kant (Author), Madeleine Noonan-Shueh (Author), Tulasikumari Kanipakala (Author), Grant Liao (Author), Sergey Shulenin (Author), Daisy W. Leung (Author), Richard A. Alm (Author), Rajan P. Adhikari (Author), Gaya K. Amarasinghe (Author), Michael L. Gross (Author), M. Javad Aman (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Staphylococcus aureus carries an exceptional repertoire of virulence factors that aid in immune evasion. Previous single-target approaches for S. aureus-specific vaccines and monoclonal antibodies (mAbs) have failed in clinical trials due to the multitude of virulence factors released during infecti...