Human induced pluripotent stem cells‐derived liver organoids grown on a Biomimesys® hyaluronic acid‐based hydroscaffold as a new model for studying human lipoprotein metabolism

• Main Authors: Meryl Roudaut (Author), Amandine Caillaud (Author), Zied Souguir (Author), Lise Bray (Author), Aurore Girardeau (Author), Antoine Rimbert (Author), Mikaël Croyal (Author), Gilles Lambert (Author), Murielle Patitucci (Author), Gaspard Delpouve (Author), Élodie Vandenhaute (Author), Cédric Le May (Author), Nathalie Maubon (Author), Bertrand Cariou (Author), Karim Si‐Tayeb (Author)
• Format: Book
• Published: Wiley, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The liver plays a key role in the metabolism of lipoproteins, controlling both production and catabolism. To accelerate the development of new lipid‐lowering therapies in humans, it is essential to have a relevant in vitro study model available. The current hepatocyte‐like cells (HLCs) mode...