Extending the in vivo Half-Life of Adalimumab Fab via Sortase A-Mediated Conjugation of Adalimumab Fab with Modified Fatty Acids

• Principais autores: Qing-Bin Zhang (Autor), Si-Da Ruan (Autor), Yong Wu (Autor), Jin-Hua Zhang (Autor), Jian-Guang Lu (Autor), Jun Feng (Autor)
• Formato: Livro
• Publicado em: Georg Thieme Verlag KG, 2020-12-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Adalimumab, a full-length monoclonal antibody, is widely used as an anti-tumor necrosis factor-α (anti-TNF-α) agent. In this article, we aimed to prolong the in vivo half-life of adalimumab antigen-binding fragment (Fab) through Sortase A (SrtA)-mediated conjugation of its Fab with fatty acid (FA)....