Impact of Insulin Tregopil and Its Permeation Enhancer on Pharmacokinetics of Metformin in Healthy Volunteers: Randomized, Open‐Label, Placebo‐Controlled, Crossover Study

• Egile Nagusiak: Anand Khedkar (Egilea), Harold Lebovitz (Egilea), Alexander Fleming (Egilea), Alan Cherrington (Egilea), Vinu Jose (Egilea), Sandeep N. Athalye (Egilea), Ashwini Vishweswaramurthy (Egilea)
• Formatua: Liburua
• Argitaratua: Wiley, 2019-05-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Oral insulin tregopil (IN‐105; a new drug under development) may be coadministered with oral antidiabetic drugs, such as metformin in patients with type 2 diabetes mellitus for optimal glycemic control. IN‐105 has sodium caprate excipient, a permeation enhancer, for enhancing absorption in the stoma...