Mutations in the pfmdr1, cg2, and pfcrt genes in Plasmodium falciparum samples from endemic malaria areas in Rondonia and Pará State, Brazilian Amazon Region Mutações nos genes pfmdr1, cg2 e pfcrt em isolados de Plasmodium falciparum provenientes de localidades malarígenas dos Estados de Rondônia e Pará, Amazônia Legal Brasileira

• Main Authors: Giselle Maria Rachid Viana (Author), Ricardo Luís Dantas Machado (Author), Vanja Sueli Pachiano Calvosa (Author), Marinete Marins Póvoa (Author)
• Format: Book
• Published: Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz, 2006-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The objectives of this study were to investigate the molecular basis for Plasmodium falciparum resistance to chloroquine in isolates from the Brazilian Amazon and to identify polymorphisms in the pfmdr1 gene, codons 184, 1042, and 1246, the kappa and gamma regions of the cg2 gene, and the K76T mutat...