Preclinical and Clinical Pharmacology of Hydrocodone for Chronic Pain: A Mini Review

• Main Authors: Luigi Cardia (Author), Gioacchino Calapai (Author), Domenico Quattrone (Author), Cristina Mondello (Author), Vincenzo Arcoraci (Author), Fabrizio Calapai (Author), Carmen Mannucci (Author), Epifanio Mondello (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hydrocodone is one of the most prescribed oral analgesic drugs and it is one of the most abused drugs in general population. It is a mu-opioid agonist predominantly metabolized to the O-demethylated product hydromorphone and to the N-demethylated product norhydrocodone. The purpose of the study is t...