Nuclear TIGAR mediates an epigenetic and metabolic autoregulatory loop via NRF2 in cancer therapeutic resistance

• Main Authors: Hong Wang (Author), Qianqian Wang (Author), Guodi Cai (Author), Zhijian Duan (Author), Zoann Nugent (Author), Jie Huang (Author), Jianwei Zheng (Author), Alexander D. Borowsky (Author), Jian Jian Li (Author), Peiqing Liu (Author), Hsing-Jien Kung (Author), Leigh Murphy (Author), Hong-Wu Chen (Author), Junjian Wang (Author)
• Format: Book
• Published: Elsevier, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Metabolic and epigenetic reprogramming play important roles in cancer therapeutic resistance. However, their interplays are poorly understood. We report here that elevated TIGAR (TP53-induced glycolysis and apoptosis regulator), an antioxidant and glucose metabolic regulator and a target of oncogeni...