Targeting Insulin Receptor with a Novel Internalizing Aptamer

• Main Authors: Margherita Iaboni (Author), Raffaela Fontanella (Author), Anna Rienzo (Author), Maria Capuozzo (Author), Silvia Nuzzo (Author), Gianluca Santamaria (Author), Silvia Catuogno (Author), Gerolama Condorelli (Author), Vittorio de Franciscis (Author), Carla Lucia Esposito (Author)
• Format: Book
• Published: Elsevier, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nucleic acid-based aptamers are emerging as therapeutic antagonists of disease-associated proteins such as receptor tyrosine kinases. They are selected by an in vitro combinatorial chemistry approach, named Systematic Evolution of Ligands by Exponential enrichment (SELEX), and thanks to their small...