Formulated Phospholipids as Non-Canonical TLR4 Agonists

• Main Authors: Hong Liang (Author), William R. Lykins (Author), Emilie Seydoux (Author), Jeffrey A. Guderian (Author), Tony Phan (Author), Christopher B. Fox (Author), Mark T. Orr (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Immunogenic agents known as adjuvants play a critical role in many vaccine formulations. Adjuvants often signal through Toll-like receptor (TLR) pathways, including formulations in licensed vaccines that target TLR4. While TLR4 is predominantly known for responding to lipopolysaccharide (LPS), a com...