Deciphering the mechanism of PSORI-CM02 in suppressing keratinocyte proliferation through the mTOR/HK2/glycolysis axis

• Main Authors: Maojie Wang (Author), Bin Tang (Author), Huanjie Huang (Author), Xiaodong Wu (Author), Hao Deng (Author), Haiming Chen (Author), Liyan Mei (Author), Xiumin Chen (Author), Boudewijn Burgering (Author), Chuanjian Lu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hyperplasia of epidermal keratinocytes that depend on glycolysis is a new hallmark of psoriasis pathogenesis. Our previous studies demonstrated that PSORI-CM02 could halt the pathological progression of psoriasis by targeting inflammatory response and angiogenesis, but its effect(s) and mechanism(s)...